A plakophilin-1 gene mutation in an egyptian family with ectodermal dysplasia-skin fragility syndrome.

ABSTRACT: Ectodermal dysplasia-skin fragility syndrome (ED-SFS) is a rare genodermatosis caused by mutations in the PKP1 gene, encoding the desmosomal plaque protein plakophilin-1. Since its initial description in 1997, few individuals with this disorder have been reported to date. Here, we present the first Egyptian cases of ED-SFS, carrying a novel homozygous mutation in the PKP1 gene. Direct sequencing of the amplified DNA from the affected cases disclosed a G-to-T transversion at nucleotide position c.203-1 within intron 1 of PKP1 (c.203-1G>T). To the best of our knowledge, this mutation has not been previously described in the databases.

SUBMITTER: Abdalla EM 

PROVIDER: S-EPMC4281574 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature