Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.

ABSTRACT: K(+) channels fulfill roles spanning from the control of excitability to the regulation of transepithelial transport. Here we review two groups of K(+) channels, pH-regulated K2P channels and the transport group of Kir channels. After considering advances in the molecular aspects of their gating based on structural and functional studies, we examine their participation in certain chosen physiological and pathophysiological scenarios. Crystal structures of K2P and Kir channels reveal rather unique features with important consequences for the gating mechanisms. Important tasks of these channels are discussed in kidney physiology and disease, K(+) homeostasis in the brain by Kir channel-equipped glia, and central functions in the hearing mechanism in the inner ear and in acid secretion by par

SUBMITTER: Sepulveda FV 

PROVIDER: S-EPMC4281587 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature