Inducible glutamate oxaloacetate transaminase as a therapeutic target against ischemic stroke.

ABSTRACT:

Significance

Glutamate serves multi-faceted (patho)physiological functions in the central nervous system as the most abundant excitatory neurotransmitter and under pathological conditions as a potent neurotoxin. Regarding the latter, elevated extracellular glutamate is known to play a central role in ischemic stroke brain injury.

Recent advances

Glutamate oxaloacetate transaminase (GOT) has emerged as a new therapeutic target in protecting against ischemic stroke injury. Oxygen-sensitive induction of GOT expression and activity during ischemic stroke lowers glutamate levels at the stroke site while sustaining adenosine triphosphate levels in brain. The energy demands of the brain are among the highest of all organs underscoring the need to quickly mobilize alternative carbon

SUBMITTER: Khanna S 

PROVIDER: S-EPMC4281871 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature