A genetic-based approach to personalized prostate cancer screening and treatment.

ABSTRACT:

Purpose of review

Recent advances in sequencing technologies have allowed for the identification of genetic variants within germline DNA that can explain a significant portion of the genetic underpinnings of prostate cancer. Despite evidence suggesting that these genetic variants can be used for improved risk stratification, they have not yet been routinely incorporated into routine clinical practice. This review highlights their potential utility in prostate cancer screening.

Recent findings

There are now almost 100 genetic variants, called single nucleotide polymorphisms (SNPs) that have been recently found to be associated with the risk of developing prostate cancer. In addition, some of these prostate cancer risk SNPs have also been found to influence prostate specific a

SUBMITTER: Helfand BT 

PROVIDER: S-EPMC4281884 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature