Identification of secreted glycoproteins of human prostate and bladder stromal cells by comparative quantitative proteomics.

ABSTRACT:

Background

Functional development of the prostate is governed by stromal mesenchyme induction and epithelial response. Stromal/epithelial signaling can be mediated through direct cell-cell contact and diffusible factors and their cell surface receptors. These inducers are likely secreted or membrane-associated extracellular proteins. Given the importance of intercellular communication, it is possible that diseases like cancer could arise from a loss of this communication. One approach to gain a molecular understanding of stromal cells is to identify, as a first step, secreted stromal signaling factors. We proposed to do this by comparative analysis between bladder and prostate.

Methods

Secreted proteins were identified from cultured normal prostate and bladder stromal mesenc

SUBMITTER: Goo YA 

PROVIDER: S-EPMC4281891 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature