Evaluation of a novel nicotine inhaler device: part 2--effect on craving and smoking urges.

ABSTRACT:

Introduction

Many smokers find currently available nicotine replacement therapies unsatisfactory. The pharmacokinetics of nicotine delivered via a novel inhaler device, and its effect on craving satiation and smoking urges, were compared with the Nicorette® Inhalator (10 mg).

Methods

Results are reported for Parts B (N = 24) and D (N = 24) of a 4-part Phase I study. Participants (18-55 years, ≥ 10 cigarettes/day within 1 hr of waking, expired carbon monoxide >10 ppm on screening) received single doses of nicotine on consecutive days (0.45 and 0.67 mg [Part B] and 0.45 mg [Part D] via the novel device; 10 mg via Nicorette® [Parts B and D]). Venous pharmacokinetics, craving, and tolerability were assessed.

Results

In Part B, the novel device 0.45 and 0.67 mg produced si

SUBMITTER: Moyses C 

PROVIDER: S-EPMC4282120 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature