Morphological abnormalities of the thalamus in youths with attention deficit hyperactivity disorder.

ABSTRACT:

Objective

The role of the thalamus in the genesis of attention deficit hyperactivity disorder (ADHD) remains poorly understood. The authors used anatomical MRI to examine the morphology of the thalamus in youths with ADHD and healthy comparison youths.

Method

The authors examined 46 youths with ADHD and 59 comparison youths 8-18 years of age in a cross-sectional case-control study. Conventional volumes and measures of surface morphology of the thalamus served as the main outcome measures.

Results

A mixed-effects model comparing whole thalamic volumes revealed no significant differences between groups. Maps of the thalamic surface revealed significantly smaller regional volumes bilaterally in the pulvinar in youths with ADHD relative to comparison subjects. Post hoc an

SUBMITTER: Ivanov I 

PROVIDER: S-EPMC4282161 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature