Distinguishing adrenal cortical carcinomas and adenomas: a study of clinicopathological features and biomarkers.

ABSTRACT:

Aims

To determine clinicopathological criteria and molecular markers helpful in distinguishing adrenocortical carcinomas (ACCs) from adrenocortical adenomas (ACAs).

Methods and results

We analysed retrospectively the clinical and pathological features of 50 adrenal cortical tumours, and tested the expression of miR483-3p by in-situ hybridization as well as the expression of IGF2 and Smad4 by immunohistochemistry. We found that tumour size, tumour weight, hormonal function and the Weiss system are all high-efficacy criteria for differentiating malignant from benign tumours (P < 0.001). MiR483-3p was overexpressed in 68% (17 of 25) of ACCs compared to 12% (three of 25) of ACAs (P < 0.05). Using a combination of miR483-3p and Smad4 improved diagnostic accuracy. Molecular marker

SUBMITTER: Wang C 

PROVIDER: S-EPMC4282325 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature