A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia.

ABSTRACT:

Aims

Hippocampal sclerosis (HS) is long-recognized in association with epilepsy (HSE ) and more recently in the context of cognitive decline or dementia in the elderly (HSD ), in some cases as a component of neurodegenerative diseases, including Alzheimer's disease (AD) and fronto-temporal lobe dementia (FTLD). There is an increased risk of seizures in AD and spontaneous epileptiform discharges in the dentate gyrus of transgenic AD models; epilepsy can be associated with an age-accelerated increase in AD-type pathology and cognitive decline. The convergence between these disease processes could be related to hippocampal pathology. HSE typically shows re-organization of both excitatory and inhibitory neuronal networks in the dentate gyrus, and is considered to be relevant to hippoca

SUBMITTER: Bandopadhyay R 

PROVIDER: S-EPMC4282449 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature