Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival.

ABSTRACT:

Rationale

Yes-associated protein (YAP), the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEA (transcriptional enhancer activator)-domain sequence-specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the direct transcriptional targets through which YAP exerts its effects are poorly defined.

Objective

To identify direct YAP targets that mediate its mitogenic and antiapoptotic effects in the heart.

Methods and results

We identified direct YAP targets by combining differential gene expression analysis in YAP gain- and loss-of-function with genome-wide identification of YAP-bound loci using chromatin immunoprecip

SUBMITTER: Lin Z 

PROVIDER: S-EPMC4282610 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature