Ontology highlight
ABSTRACT:
SUBMITTER: Voss M
PROVIDER: S-EPMC4282638 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
The EMBO journal 20141029 24
Protein N-glycosylation is involved in a variety of physiological and pathophysiological processes such as autoimmunity, tumour progression and metastasis. Signal peptide peptidase-like 3 (SPPL3) is an intramembrane-cleaving aspartyl protease of the GxGD type. Its physiological function, however, has remained enigmatic, since presently no physiological substrates have been identified. We demonstrate that SPPL3 alters the pattern of cellular N-glycosylation by triggering the proteolytic release o ...[more]