Dentate gyrus abnormalities in sudden unexplained death in infants: morphological marker of underlying brain vulnerability.

ABSTRACT: Sudden unexplained death in infants, including the sudden infant death syndrome, is likely due to heterogeneous causes that involve different intrinsic vulnerabilities and/or environmental factors. Neuropathologic research focuses upon the role of brain regions, particularly the brainstem, that regulate or modulate autonomic and respiratory control during sleep or transitions to waking. The hippocampus is a key component of the forebrain-limbic network that modulates autonomic/respiratory control via brainstem connections, but its role in sudden infant death has received little attention. We tested the hypothesis that a well-established marker of hippocampal pathology in temporal lobe epilepsy-focal granule cell bilamination in the dentate, a variant of granule cell dispersion-is associate

SUBMITTER: Kinney HC 

PROVIDER: S-EPMC4282685 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature