Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut.

ABSTRACT:

Background

The management of peanut allergy relies on allergen avoidance and epinephrine autoinjector for rescue treatment in patients at risk of anaphylaxis. Biomarkers of severity and threshold of allergic reactions to peanut could significantly improve the care for patients with peanut allergy.

Objective

We sought to assess the utility of the basophil activation test (BAT) to predict the severity and threshold of reactivity to peanut during oral food challenges (OFCs).

Methods

The severity of the allergic reaction and the threshold dose during OFCs to peanut were determined. Skin prick tests, measurements of specific IgE to peanut and its components, and BATs to peanut were performed on the day of the challenge.

Results

Of the 124 children submitted to OFCs

SUBMITTER: Santos AF 

PROVIDER: S-EPMC4282725 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature