Association of apolipoprotein A5 genetic polymorphisms with steroid-induced osteonecrosis of femoral head in a Chinese Han population.

ABSTRACT:

Background

Previous studies suggested that apolipoprotein A5 (ApoA5) genetic polymorphisms (SNPs) may result in lipid metabolism disorders. Therefore, genetic polymorphisms in ApoA5 may be associated with the occurrence of osteonecrosis of femoral head (ONFH).

Methods

We designed a case-control study including 223 patients of osteonecrosis and 201 age- and sex-matched control subjects to analyze the association between ApoA5 polymorphisms and susceptibility of steroid-induced ONFH. We utilized polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to genotype two SNPs (rs662799 and rs3135506) in ApoA5 gene.

Results

We found both rs662799 and rs3135506 were associated with the risk of ONFH in codominant, dominant, and recessive model, resp

SUBMITTER: Cui Y 

PROVIDER: S-EPMC4282735 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature