Ligand-based molecular MRI: O-17 JJVCPE amyloid imaging in transgenic mice.

ABSTRACT:

Background

Development of molecular MR imaging (MRI) similar to PET imaging using contrast agents such as gadolinium as probe have been inherently hampered by incompatibility between potential probe (charged molecules) and membrane permeability. Nevertheless, considering the inherent spatial resolution limit for PET of 700μ, the superior microscopic resolution of MRI of 4 μ presents a strong incentive for research into ligand-based molecular MRI.

Methods

(17) O exhibits JJ vicinal coupling with a covalently bound proton in a hydroxyl group. This (17) O coupled proton can be ionized in water solution and interexchange with other water protons. This property can be utilized as "probe" in T2-weighted imaging and developed into ligand-based molecular MRI. We examined β-amyloid d

SUBMITTER: Suzuki K 

PROVIDER: S-EPMC4282752 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature