A pilot randomized crossover trial assessing the safety and short-term effects of pomegranate supplementation in hemodialysis patients.

ABSTRACT:

Objective

Oxidative stress and systemic inflammation are highly prevalent in patients undergoing maintenance hemodialysis (MHD) and are linked to excess cardiovascular risk. This study examined whether short-term supplementation with pomegranate juice and extract is safe and well tolerated by MHD patients. The secondary aim was to assess the effect of pomegranate supplementation on oxidative stress, systemic inflammation, monocyte function, and blood pressure.

Design

Prospective, randomized, crossover, pilot clinical trial (NCT01562340).

Setting

The study was conducted from March to October 2012 in outpatient dialysis facilities in the Seattle metropolitan area.

Subjects

Twenty-four patients undergoing MHD (men, 64%; mean age, 61 ± 14 years) were randomly assig

SUBMITTER: Rivara MB 

PROVIDER: S-EPMC4282815 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature