Antigen recognition in the islets changes with progression of autoimmune islet infiltration.

ABSTRACT: In type 1 diabetes, the pancreatic islets are an important site for therapeutic intervention because immune infiltration of the islets is well established at diagnosis. Therefore, understanding the events that underlie the continued progression of the autoimmune response and islet destruction is critical. Islet infiltration and destruction is an asynchronous process, making it important to analyze the disease process on a single islet basis. To understand how T cell stimulation evolves through the process of islet infiltration, we analyzed the dynamics of T cell movement and interactions within individual islets of spontaneously autoimmune NOD mice. Using both intravital and explanted two-photon islet imaging, we defined a correlation between increased islet infiltration and increased T ce

SUBMITTER: Lindsay RS 

PROVIDER: S-EPMC4282963 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature