Lack of Serum anti-Mullerian hormone responses after recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome.

ABSTRACT:

Context

Polycystic ovary syndrome (PCOS) is an anovulatory disorder characterized by excess androgen production and increased LH secretion. Serum anti-Mullerian hormone (AMH) is also elevated in this disorder. Women with PCOS exhibit a positive correlation between AMH and LH levels and recent in vitro data demonstrate that LH can directly stimulate AMH production by granulosa cells from women with PCOS.

Objective

The objective of the study was to directly test whether LH increases AMH production in women with PCOS in vivo by assessing responses after recombinant human chorionic gonadotropin (r-hCG) stimulation.

Design

This was a prospective study.

Setting

The study was conducted at a research center at an academic medical center.

Participants

Women with

SUBMITTER: Cook-Andersen H 

PROVIDER: S-EPMC4283023 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature