MiRNA-30 family inhibition protects against cardiac ischemic injury by regulating cystathionine-γ-lyase expression.

ABSTRACT:

Aims

Myocardial infarction (MI) is a leading cause of death globally. MicroRNAs (miRNAs) have been identified as a novel class of MI injury regulators. Hydrogen sulfide (H2S) is a gaseous signaling molecule that regulates cardiovascular function. The purpose of this study was to explore the role of the miR-30 family in protecting against MI injury by regulating H2S production.

Results

The expression of miR-30 family was upregulated in the murine MI model as well as in the primary cardiomyocyte hypoxic model. However, the cystathionine-γ-lyase (CSE) expression was significantly decreased. The overexpression of miR-30 family decreased CSE expression, reduced H2S production, and then aggravated hypoxic cardiomyocyte injury. In contrast, silencing the whole miR-30 family can pro

SUBMITTER: Shen Y 

PROVIDER: S-EPMC4283074 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature