Statin therapy after infrainguinal bypass surgery for critical limb ischemia is associated with improved 5-year survival.

ABSTRACT:

Objective

Although statin therapy has been linked to fewer short-term complications after infrainguinal bypass, its effect on long-term survival remains unclear. We therefore examined associations between statin use and long-term mortality, graft occlusion, and amputation after infrainguinal bypass.

Methods

We used the Vascular Study Group of New England registry to study 2067 patients (71% male; mean age, 67 ± 11 years; 67% with critical limb ischemia [CLI]) who underwent infrainguinal bypass from 2003 to 2011. Of these, 1537 (74%) were on statins perioperatively and at 1-year follow-up, and 530 received no statin. We examined crude, adjusted, and propensity-matched rates of 5-year surviva1, 1-year amputation, graft occlusion, and perioperative myocardial infarction.

Res

SUBMITTER: Suckow BD 

PROVIDER: S-EPMC4283106 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature