A better understanding of why murine models of trauma do not recapitulate the human syndrome.

ABSTRACT:

Objective

Genomic analyses from blood leukocytes have concluded that mouse injury poorly reflects human trauma at the leukocyte transcriptome. Concerns have focused on the modest severity of murine injury models, differences in murine compared with human age, dissimilar circulating leukocyte populations between species, and whether similar signaling pathways are involved. We sought to examine whether the transcriptomic response to severe trauma in mice could be explained by these extrinsic factors, by utilizing an increasing severity of murine trauma and shock in young and aged mice over time, and by examining the response in isolated neutrophil populations.

Design

Preclinical controlled in vivo laboratory study and retrospective cohort study.

Setting

Laboratory of In

SUBMITTER: Gentile LF 

PROVIDER: S-EPMC4283139 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature