A comprehensive analysis of aquaporin and secretory related gene expression in neonate and adult cholangiocytes.

ABSTRACT: Canalicular bile is secreted by hepatocytes and then passes through the intrahepatic bile ducts, comprised of cholangiocytes, to reach the extrahepatic biliary system. In addition to providing a conduit for bile to drain from the liver, cholangiocytes play an active role in modifying bile composition. Bile formation is the result of a series of highly coordinated intricate membrane-transport interactions. Proper systematic regulation of solute and water transport is critical for both digestion and the health of the liver, yet our knowledge of cholangiocyte water and ion transporters and their relative expression patterns remains incomplete. In this report, we provide a comprehensive expression profile of the aquaporin (AQP) family and three receptors/channels known to regulate ion transpor

SUBMITTER: Poling HM 

PROVIDER: S-EPMC4283140 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature