Ontology highlight
ABSTRACT:
SUBMITTER: Stern-Ginossar N
PROVIDER: S-EPMC4283197 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20070701 5836
Virally encoded microRNAs (miRNAs) have recently been discovered in herpesviruses. However, their biological roles are mostly unknown. We developed an algorithm for the prediction of miRNA targets and applied it to human cytomegalovirus miRNAs, resulting in the identification of the major histocompatibility complex class I-related chain B (MICB) gene as a top candidate target of hcmv-miR-UL112. MICB is a stress-induced ligand of the natural killer (NK) cell activating receptor NKG2D and is criti ...[more]