The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.

ABSTRACT: Macrophages regulate lymphatic vasculature development; however, the molecular mechanisms regulating their recruitment to developing, and adult, lymphatic vascular sites are not known. Here, we report that resting mice deficient for the inflammatory chemokine-scavenging receptor, ACKR2, display increased lymphatic vessel density in a range of tissues under resting and regenerating conditions. This appears not to alter dendritic cell migration to draining lymph nodes but is associated with enhanced fluid drainage from peripheral tissues and thus with a hypotensive phenotype. Examination of embryonic skin revealed that this lymphatic vessel density phenotype is developmentally established. Further studies indicated that macrophages and the inflammatory CC-chemokine CCL2, which is scavenged b

SUBMITTER: Lee KM 

PROVIDER: S-EPMC4283412 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature