Validation of a score tool for measurement of histological severity in juvenile dermatomyositis and association with clinical severity of disease.

ABSTRACT:

Objectives

To study muscle biopsy tissue from patients with juvenile dermatomyositis (JDM) in order to test the reliability of a score tool designed to quantify the severity of histological abnormalities when applied to biceps humeri in addition to quadriceps femoris. Additionally, to evaluate whether elements of the tool correlate with clinical measures of disease severity.

Methods

55 patients with JDM with muscle biopsy tissue and clinical data available were included. Biopsy samples (33 quadriceps, 22 biceps) were prepared and stained using standardised protocols. A Latin square design was used by the International Juvenile Dermatomyositis Biopsy Consensus Group to score cases using our previously published score tool. Reliability was assessed by intraclass correlation co

SUBMITTER: Varsani H 

PROVIDER: S-EPMC4283618 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature