Biomarkers identified with time-lapse imaging: discovery, validation, and practical application.

ABSTRACT: "Time-lapse markers," which are defined by time-lapse imaging and correlated with clinical outcomes, may provide embryologists with new opportunities for improving embryo selection. This article provides an overview of noninvasive biomarkers defined by time-lapse imaging studies. In addition to comprehensively reviewing the discovery of each time-lapse marker, it focuses on the criteria necessary for their successful integration into clinical practice, including [1] statistical and biological significance, [2] validation through prospective clinical studies, and [3] development of reliable technology to measure and quantify the time-lapse marker. Because manual analysis of time-lapse images is labor intensive and limits the practical use of the image data in the clinic, automated image ana

SUBMITTER: Chen AA 

PROVIDER: S-EPMC4283765 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature