From beat rate variability in induced pluripotent stem cell-derived pacemaker cells to heart rate variability in human subjects.

ABSTRACT:

Background

We previously reported that induced pluripotent stem cell-derived cardiomyocytes manifest beat rate variability (BRV) resembling heart rate variability (HRV) in the human sinoatrial node. We now hypothesized the BRV-HRV continuum originates in pacemaker cells.

Objective

To investigate whether cellular BRV is a source of HRV dynamics, we hypothesized 3 levels of interaction among different cardiomyocyte entities: (1) single pacemaker cells, (2) networks of electrically coupled pacemaker cells, and (3) the in situ sinoatrial node.

Methods

We measured BRV/HRV properties in single pacemaker cells, induced pluripotent stem cell-derived contracting embryoid bodies (EBs), and electrocardiograms from the same individual.

Results

Pronounced BRV/HRV was presen

SUBMITTER: Ben-Ari M 

PROVIDER: S-EPMC4283811 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature