In Vitro Study of Directly Bioprinted Perfusable Vasculature Conduits.

ABSTRACT: The ability to create three dimensional (3D) thick tissues is still a major tissue engineering challenge. It requires the development of a suitable vascular supply for an efficient media exchange. An integrated vasculature network is particularly needed when building thick functional tissues and/or organs with high metabolic activities, such as the heart, liver and pancreas. In this work, human umbilical vein smooth muscle cells (HUVSMCs) were encapsulated in sodium alginate and printed in the form of vasculature conduits using a coaxial deposition system. Detailed investigations were performed to understand the dehydration, swelling and degradation characteristics of printed conduits. In addition, because perfusional, permeable and mechanical properties are unique characteristics of natur

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4283831 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature