Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in Mugla province.

ABSTRACT: INTRODUCTION:Chronic obstructive pulmonary disease (COPD) is an irreversible progressive chronic inflammatory disease that causes shortness of breath in consequence of a decrease in pulmonary functions. The pulmonary inflammatory pathogenesis is multifactorial. We have too little up-to-date information about the relation between COPD and genetics. In our study, the relation with the SIRT1 gene's mononucleotide polymorphisms (SNP) rs7895833, rs7069102 and rs2273773 was analyzed through various laboratory data. MATERIAL AND METHODS:One hundred COPD patients from the archive records of the Chest Diseases Department of Muğla Sitki Kocman University Medical Faculty were included in the study. A control group was constituted from 100 healthy individuals who live in the same geographical region.

SUBMITTER: Kalemci S 

PROVIDER: S-EPMC4283875 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature