Total synthesis of plagiochin G and derivatives as potential cancer chemopreventive agents.

ABSTRACT: A new and efficient total synthesis has been developed to obtain plagiochin G (22), a macrocyclic bisbibenzyl, and four derivatives. The key 16-membered ring containing biphenyl ether and biaryl units was closed via an intramolecular S_NAr reaction. All synthesized macrocyclic bisbibenzyls inhibited Epstein-Barr virus early antigen (EBVEA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and, thus, are potential cancer chemopreventive agents.

SUBMITTER: Li RJ 

PROVIDER: S-EPMC4283946 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature