Nanodelivery of Parthenolide Using Functionalized Nanographene Enhances its Anticancer Activity.

ABSTRACT: Advances in anticancer chemotherapy have been hindered by the lack of biocompatibility of new prospective drugs. One significant challenge concerns water insolubility, which compromises the bioavailability of the drugs leading to increased dosage and higher systemic toxicity. To overcome these problems, nanodelivery has been established as a promising approach for increasing the efficacy and lowering the required dosage of chemotherapeutics. The naturally derived compound, parthenolide (PTL), is known for its anti-inflammatory and anticancer activity, but its poor water solubility limits its clinical value. In the present study, we have used carboxyl-functionalized nanographene (fGn) delivery to overcome the extreme hydrophobicity of this drug. A water-soluble PTL analog, dimethylamino par

SUBMITTER: Karmakar A 

PROVIDER: S-EPMC4283950 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature