Parental celiac disease and risk of asthma in offspring: a Danish nationwide cohort study.

ABSTRACT:

Objective

The incidences of celiac disease (CD) and asthma are increasing and the two conditions are associated in individuals. Risk of asthma may be passed on to the next generation through shared risk factors. We examined whether parental CD is associated with risk of asthma in offspring.

Methods

We conducted a population-based Danish nationwide cohort study, using medical databases, covering the period 1 January 1979 to 31 December 2009. For each child with a parental history of CD, we randomly sampled 100 children without this history from the children born in the same calendar year. We used Cox proportional-hazards regression to estimate incidence rate ratios for asthma, adjusting for measured covariates.

Results

We identified 1,107 children with a parental histo

SUBMITTER: Andersen AB 

PROVIDER: S-EPMC4283989 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature