Smoking and life expectancy among HIV-infected individuals on antiretroviral therapy in Europe and North America.

ABSTRACT:

Background

Cardiovascular disease and non-AIDS malignancies have become major causes of death among HIV-infected individuals. The relative impact of lifestyle and HIV-related factors are debated.

Methods

We estimated associations of smoking with mortality more than 1 year after antiretroviral therapy (ART) initiation among HIV-infected individuals enrolled in European and North American cohorts. IDUs were excluded. Causes of death were assigned using standardized procedures. We used abridged life tables to estimate life expectancies. Life-years lost to HIV were estimated by comparison with the French background population.

Results

Among 17,995 HIV-infected individuals followed for 79,760 person-years, the proportion of smokers was 60%. The mortality rate ratio (MRR) c

SUBMITTER: Helleberg M 

PROVIDER: S-EPMC4284008 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature