Assessment of fully automated antibody homology modeling protocols in molecular operating environment.
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ABSTRACT:
SUBMITTER: Maier JK
PROVIDER: S-EPMC4284016 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Assessment of fully automated antibody homology modeling protocols in molecular operating environment.
Maier Johannes K X JK Labute Paul P
Proteins 20140423 8
The success of antibody-based drugs has led to an increased demand for predictive computational tools to assist antibody engineering efforts surrounding the six hypervariable loop regions making up the antigen binding site. Accurate computational modeling of isolated protein loop regions can be quite difficult; consequently, modeling an antigen binding site that includes six loops is particularly challenging. In this work, we present a method for automatic modeling of the FV region of an immunog ...[more]
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