Endogenous cerebellar neurogenesis in adult mice with progressive ataxia.

ABSTRACT:

Objective

Transplanting exogenous neuronal progenitors to replace damaged neurons in the adult brain following injury or neurodegenerative disorders and achieve functional amelioration is a realistic goal. However, studies so far have rarely taken into consideration the preexisting inflammation triggered by the disease process that could hamper the effectiveness of transplanted cells. Here, we examined the fate and long-term consequences of human cerebellar granule neuron precursors (GNP) transplanted into the cerebellum of Harlequin mice, an adult model of progressive cerebellar degeneration with early-onset microgliosis.

Methods

Human embryonic stem cell-derived progenitors expressing Atoh1, a transcription factor key to GNP specification, were generated in vitro and stere

SUBMITTER: Kumar M 

PROVIDER: S-EPMC4284123 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature