Reductions in red blood cell 2,3-diphosphoglycerate concentration during continuous renal replacment therapy.

ABSTRACT:

Background and objectives

Hypophosphatemia is a frequent complication during continuous renal replacement therapy (CRRT), a dialytic technique used to treat AKI in critically ill patients. This study sought to confirm that phosphate depletion during CRRT may decrease red blood cell (RBC) concentration of 2,3-diphosphoglycerate (2,3-DPG), a crucial allosteric effector of hemoglobin's (Hgb's) affinity for oxygen, thereby leading to impaired oxygen delivery to peripheral tissues.

Design, setting, participants, & measurements

Phosphate mass balance studies were performed in 20 patients with severe AKI through collection of CRRT effluent. RBC concentrations of 2,3-DPG, venous blood gas pH, and oxygen partial pressure required for 50% hemoglobin saturation (P50) were measured at C

SUBMITTER: Sharma S 

PROVIDER: S-EPMC4284404 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature