Association of urine α1-microglobulin with kidney function decline and mortality in HIV-infected women.

ABSTRACT:

Background and objectives

Despite advances in therapy, HIV-infected individuals remain at higher risk for kidney dysfunction than uninfected individuals. It was hypothesized that urine levels of α1-microglobulin, a biomarker of proximal tubular dysfunction, would predict kidney function decline and mortality risk in HIV-infected and uninfected women.

Design, setting, participants, & measurements

In the Women's Interagency HIV Study, urine α1-microglobulin and creatinine concentrations were measured in 903 HIV-infected and 287 uninfected women using stored urine from 1999 to 2000, when prevalence of tenofovir use was <1%. Participants were categorized into three categories by level of α1-microglobulin-to-creatinine ratio, and associations with kidney decline and all-cause mor

SUBMITTER: Jotwani V 

PROVIDER: S-EPMC4284407 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature