Fibroblast growth factor 23 and incident CKD in type 2 diabetes.

ABSTRACT:

Background and objectives

High levels of fibroblast growth factor 23 are associated with accelerated progression of CKD. Whether high fibroblast growth factor 23 levels also predict incident CKD is uncertain.

Design, setting, participants, & measurements

A prospective case-cohort study was conducted within the Action to Control Cardiovascular Risk in Diabetes Trial. The analytic sample consisted of a random subcohort of 590 patients with type 2 diabetes without prevalent CKD at baseline, 124 of whom developed incident CKD during follow-up, and 520 additional patients with incident CKD outside the random subcohort. The association between serum intact fibroblast growth factor 23 and incident CKD, defined as the new onset of eGFR<60 ml/min per 1.73 m(2) that represented a ≥25%

SUBMITTER: Isakova T 

PROVIDER: S-EPMC4284418 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature