Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy.

ABSTRACT:

Background and purpose

Accumulation of amyloid-β in cerebral blood vessels occurs in familial and sporadic forms of cerebral amyloid angiopathy and is a prominent feature of Alzheimer disease. However, the functional correlates of the vascular pathology induced by cerebral amyloid angiopathy and the mechanisms involved have not been fully established.

Methods

We used male transgenic mice expressing the Swedish, Iowa, and Dutch mutations of the amyloid precursor protein (Tg-SwDI) to examine the effect of cerebral amyloid angiopathy on cerebrovascular structure and function. Somatosensory cortex cerebral blood flow was monitored by laser-Doppler flowmetry in anesthetized Tg-SwDI mice and wild-type littermates equipped with a cranial window.

Results

Tg-SwDI mice exhibite

SUBMITTER: Park L 

PROVIDER: S-EPMC4284427 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature