Potentially pathogenic immune cells and networks in apparently healthy lacrimal glands.

ABSTRACT: Lacrimal glands of people over 40 years old frequently contain lymphocytic infiltrates. Relationships between histopathological presentation and physiological dysfunction are not straightforward. Data from rabbit studies have suggested that at least two immune cell networks form in healthy lacrimal glands, one responding to environmental dryness, the other to high temperatures. New findings indicate that mRNAs for several chemokines and cytokines are expressed primarily in epithelial cells; certain others are expressed in both epithelial cells and immune cells. Transcript abundances vary substantially across glands from animals that have experienced the same conditions, allowing for correlation analyses, which detect clusters that map to various cell types and to networks of coordinately f

SUBMITTER: Mircheff AK 

PROVIDER: S-EPMC4284438 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature