Reinstatement of distributed cortical oscillations occurs with precise spatiotemporal dynamics during successful memory retrieval.

ABSTRACT: Reinstatement of neural activity is hypothesized to underlie our ability to mentally travel back in time to recover the context of a previous experience. We used intracranial recordings to directly examine the precise spatiotemporal extent of neural reinstatement as 32 participants with electrodes placed for seizure monitoring performed a paired-associates episodic verbal memory task. By cueing recall, we were able to compare reinstatement during correct and incorrect trials, and found that successful retrieval occurs with reinstatement of a gradually changing neural signal present during encoding. We examined reinstatement in individual frequency bands and individual electrodes and found that neural reinstatement was largely mediated by temporal lobe theta and high-gamma frequencies. Leve

SUBMITTER: Yaffe RB 

PROVIDER: S-EPMC4284613 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature