Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA) rupture risk is currently determined based on size and symptoms. This approach does not address the rupture risk associated with small aneurysms. Given the role of matrix metalloproteinases (MMPs) in AAA weakening and rupture, we investigated the potential of MMP-targeted imaging for detection of aneurysm biology and prediction of outcome in a mouse model of AAA with spontaneous rupture.

Methods and results

Fifteen-week-old mice (n=66) were infused with angiotensin II for 4 weeks to induce AAA. Saline-infused mice (n=16) served as control. The surviving animals underwent in vivo MMP-targeted micro-single photon emission computed tomographic/computed tomographic imaging, using RP805, a technetium-99m-labeled MMP-specific tracer, foll

SUBMITTER: Golestani R 

PROVIDER: S-EPMC4284949 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature