Targeting the endoplasmic reticulum with a membrane-interactive luminescent ruthenium(ii) polypyridyl complex†Electronic supplementary information (ESI) available: Experimental details, characterization of 2 and Fig. S1-S6. See DOI: 10.1039/c3sc51725jClick here for additional data file.

ABSTRACT: The characterization and bioactivity of the dinuclear ruthenium(ii) complex [(Ru(DIP)₂)₂(tpphz)]⁴⁺ (DIP = 4,7-diphenyl-1,10-phenanthroline and tpphz = tetrapyrido[3,2-a:2',3'-c:3'',2''-h:2''',3'''-j]phenazine) is reported. This new complex is found to be luminescent in acetonitrile, where excitation into MLCT (metal-to-ligand charge-transfer) bands in the visible area of the spectrum (λ_ex = 450 nm, ε = 45 000 M^-1 cm^-1) result in red emission (λ_em,max = 620 nm, Φ_MLCT = 0.017). Aqueous in vitro binding studies indicate that this complex binds to duplex DNA with an affinity of 1.8 × 10⁶ M^-1 through a non-classical groove-b

SUBMITTER: Gill MR 

PROVIDER: S-EPMC4285105 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature