Renal pigmentation due to chronic bismuth administration in a rhesus macaque (Macaca mulatta).

ABSTRACT: Renal pigmentation due to the administration of exogenous compounds is an uncommon finding in most species. This report describes renal pigmentation and intranuclear inclusions of the proximal convoluted tubules due to chronic bismuth administration in a rhesus macaque. An 11-year-old Indian-origin rhesus macaque with a medical history of chronic intermittent vomiting had been treated with bismuth subsalicylate, famotidine, and omeprazole singly or in combination over the course of 8 years. At necropsy, the renal cortices were diffusely dark green to black. Light and electron microscopy revealed intranuclear inclusions within the majority of renal proximal tubular epithelial cells. These inclusions appeared magenta to brown when stained with hematoxylin and eosin and were negative by the Z

SUBMITTER: Johnson AL 

PROVIDER: S-EPMC4285376 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature