Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial.

ABSTRACT:

Background

Some studies have suggested reductions in blood pressure (BP)with statin treatment, particularly in persons with hypertension. Randomized trial evidence is limited.

Methods

We performed a randomized, double-blind, placebo-controlled trial with equal allocation to simvastatin, 20 mg; pravastatin sodium,40 mg; or placebo for 6 months. Nine hundred seventy-three men and women without known cardiovascular disease or diabetes mellitus, with low-density lipoprotein cholesterol screening levels of 115 to 190 mg/dL, had assessment of systolic and diastolic BP (SBP and DBP, respectively). Blood pressure values were compared for placebo vs statins by intention-to-treat (ITT) analysis. Additional analyses were performed that (1) were confined to subjects with neither high ba

SUBMITTER: Golomb BA 

PROVIDER: S-EPMC4285458 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature