Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset.

ABSTRACT:

Background & aims

Little is known about the incidence of drug-induced liver injury (DILI) and risk factors for adverse outcomes. We evaluated short-term outcomes of a large cohort of patients with DILI enrolled in an ongoing multicenter prospective study.

Methods

Data were collected from 660 adults with definite, highly likely, or probable DILI. Regression methods were used to identify risk factors for early liver-related death or liver transplantation and chronic liver injury.

Results

Patients' median age was 51.4 years; 59.5% were female and 59.1% required hospitalization. Within 6 months of DILI onset, 30 patients received liver transplants (4.5%; 95% confidence interval [CI], 3.0%-6.1%) and 32 died (5%; 95% CI, 3.2%-6.5%); 53% of the deaths were liver related. Asi

SUBMITTER: Fontana RJ 

PROVIDER: S-EPMC4285559 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature