Comparison of two dose and three dose human papillomavirus vaccine schedules: cost effectiveness analysis based on transmission model.

ABSTRACT:

Objective

To investigate the incremental cost effectiveness of two dose human papillomavirus vaccination and of additionally giving a third dose.

Design

Cost effectiveness study based on a transmission dynamic model of human papillomavirus vaccination. Two dose schedules for bivalent or quadrivalent human papillomavirus vaccines were assumed to provide 10, 20, or 30 years' vaccine type protection and cross protection or lifelong vaccine type protection without cross protection. Three dose schedules were assumed to give lifelong vaccine type and cross protection.

Setting

United Kingdom.

Population

Males and females aged 12-74 years.

Interventions

No, two, or three doses of human papillomavirus vaccine given routinely to 12 year old girls, with an initial

SUBMITTER: Jit M 

PROVIDER: S-EPMC4285892 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature