ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head susceptibility: a meta-analysis.

ABSTRACT:

Background

The results of studies on association between ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head (GANFH) are controversial. This study aimed to assess the association of ABCB1 gene polymorphisms with the risk of GANFH by conducting a meta-analysis.

Material and methods

The PubMed, Cochrane Library, and Embase databases were searched for papers that describe the association between ABCB1 polymorphisms and GANFH risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effects model or random-effects model, depending on the absence or presence of significant heterogeneity.

Results

A total of 5 studies and 833 patients were included in the final analysis. Significant differences were fou

SUBMITTER: Li Z 

PROVIDER: S-EPMC4285923 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature