Virus transcript levels and cell growth rates after naturally occurring HPV16 integration events in basal cervical keratinocytes.

ABSTRACT: Cervical carcinogenesis is characterized by a clonal selection process in which the high-risk human papillomavirus (HRHPV) genome usually changes from the extra-chromosomal (episomal) state seen in productive infections to DNA that is integrated into host chromosomes. However, it is not clear whether all HRHPV integration events provide cells with a selective growth advantage compared with the episome-containing cells from which they originate. It is also unclear whether selection of cells containing a particular integrant from a mixed population simply reflects the highest levels of virus oncogene expression or has additional determinants. These early events in cervical carcinogenesis cannot readily be addressed by cross-sectional studies of clinical samples. We used the W12 model system

SUBMITTER: Scarpini CG 

PROVIDER: S-EPMC4285939 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature