Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects.

ABSTRACT:

Background

Colonic transit tests are used to manage patients with Functional Gastrointestinal Disorders. Some tests used expose patients to ionizing radiation. The aim of this study was to compare novel magnetic resonance imaging (MRI) tests for measuring orocecal transit time (OCTT) and whole gut transit time (WGT), which also provide data on colonic volumes.

Methods

21 healthy volunteers participated. Study 1: OCTT was determined from the arrival of the head of a meal into the cecum using MRI and the Lactose Ureide breath test (LUBT), performed concurrently. Study 2: WGT was assessed using novel MRI marker capsules and radio-opaque markers (ROMs), taken on the same morning. Studies were repeated 1 week later.

Key results

OCTT measured using MRI and LUBT was 225 min

SUBMITTER: Chaddock G 

PROVIDER: S-EPMC4285997 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature